Research Articles
The Unlikely Pair: How a Sugar-Binding Protein Teams Up with DNA's Guardian to Fight Cancer
Discover the groundbreaking research revealing how galectin-3 interacts with BARD1 to influence DNA damage repair and cancer treatment resistance.
Ganetespib: The Cancer Fighter That Takes Down Multiple Enemy Lines
Explore ganetespib, an innovative HSP90 inhibitor that represents a fundamentally different strategy in cancer treatment by attacking cancer's protein support system.
The Cellular Orchestra: How Ubiquitin Pulls the Strings of the Hippo Pathway
Explore how ubiquitin modification regulates the Hippo signaling pathway, controlling organ size and influencing cancer development through sophisticated molecular mechanisms.
The Cell's Unsung Hero: How a Molecular Shredder Fights Cancer
Discover RNF144B, a newly discovered molecular shredder that prevents genomic instability and fights cancer as part of the p53 tumor suppressor pathway.
Lipid Signaling: The Molecular Language of Life and Disease
Explore the fascinating world of lipid signaling, PI3K pathways, and their crucial role in health and disease, including cancer therapeutics.
Unlocking Melanoma's Origins: The Genetic Sleuths Inside a Sleeping Fish
Discover how the Sleeping Beauty transposon system is revealing the genetic accomplices that cooperate with BRAF-V600E to drive melanoma initiation and progression.
The Dark Knight of the Genome: How p53 Acts as Your Cell's Batman
Explore how p53, the guardian of the genome, functions like Batman to control the cell cycle and prevent cancer through an engaging movie plot analogy.
The Double-Edged Sword: How USP7 Maintains Cellular Balance and Influences Cancer
Explore how Ubiquitin-Specific Peptidase 7 (USP7) regulates protein homeostasis and its dual role in cancer development and treatment.
The Hidden Guardian: How a Tiny Protein Could Revolutionize Brain Cancer Treatment
Discover how FBXO8, a tiny protein, correlates with tumor grade and prognosis in human glioma, offering new hope for brain cancer treatment.
UBR5: The Cellular Conductor Turned Cancer Villain
Explore the dual role of UBR5 E3 ubiquitin ligase in cancer progression and suppression, its mechanisms, and therapeutic targeting strategies.