Research Articles
Cracking the TDP-43 Code: How a Misfolded Protein Triggers Neurodegeneration
Exploring the role of TDP-43 protein mutations in neurodegenerative diseases like ALS and FTD, including disease mechanisms and therapeutic approaches.
When the Brain's Recycling System Fails: How Proteasome Depletion Triggers Neurodegeneration
Discover how 26S proteasome dysfunction in mouse brain neurons leads to neurodegeneration and Lewy-like inclusions resembling human pale bodies.
The Ubiquitin Saboteur: How a Mutant Protein Slowly Strangles Brain Cells
Discover how a mutant form of ubiquitin progressively impairs proteasome function in a dose-dependent manner, contributing to neurodegenerative diseases like Alzheimer's and Parkinson's.
The Mystery of the Survivors: Why Some Motor Neurons Escape Spinal Muscular Atrophy
Exploring the molecular basis of selective motor neuron vulnerability in spinal muscular atrophy using mouse models and transcriptomic analysis.
When the Brain's Cleanup Crew Fails: The Protein Problem in Parkinson's Disease
Understanding how protein quality control systems fail in Parkinson's disease and the latest research on therapeutic approaches.
The Eye as a Window: How Huntington's Disease Changes the Retina
Could an eye test one day help predict a brain disorder? New research suggests the answer might be staring back at us.
The Blood Test Revolution: Decoding Neurodegenerative Diseases
How blood-based biomarkers are revolutionizing the detection and understanding of neurodegenerative diseases like Alzheimer's and Parkinson's.
The Alpha-Synuclein Problem: The Search for Effective Treatments in Parkinson's and Related Diseases
Exploring the role of alpha-synuclein in neurodegenerative diseases and the latest therapeutic approaches targeting its toxicity in Parkinson's and related disorders.
Two Faces of One Disease: The Surprising Connection Between ALS and FTD
Discover the groundbreaking research revealing how ALS and FTD, once thought to be separate conditions, are actually two manifestations of the same underlying disease process.
When Mind and Muscle Fail: The Surprising Connection Between ALS and Frontotemporal Dementia
Exploring the overlapping characteristics of amyotrophic lateral sclerosis and frontotemporal dementia, from genetics to clinical manifestations.