Research Articles
Marine Molecule to Cancer Fighter: The Promise of Metal-Based Isatin Derivatives
Explore how metal-based isatin derivatives from marine organisms are emerging as powerful proteasome inhibitors and apoptosis inducers in human cancer cells.
The Ubiquitin Saboteur: How a Mutant Protein Slowly Strangles Brain Cells
Discover how a mutant form of ubiquitin progressively impairs proteasome function in a dose-dependent manner, contributing to neurodegenerative diseases like Alzheimer's and Parkinson's.
Unlocking a New Weapon in the Fight Against Ovarian Cancer
Discover how blocking both the Ubiquitin-Proteasome System and HDAC6-dependent lysosomal pathway creates synergistic killing of ovarian cancer cells.
NRF3: The Dark Horse of Cancer Biology and Its Unconventional Attack on Tumor Suppressors
Explore how NRF3, a transcription factor, promotes cancer progression by hijacking the proteasomal system to eliminate tumor suppressors like p53 and Rb.
Cellular "Janitors" & "Assassins": How the Ubiquitin-Proteasome System Became a New Anti-Cancer Weapon
Explore how the ubiquitin-proteasome system, the cell's protein degradation machinery, is being targeted for innovative cancer therapies like proteasome inhibitors and PROTACs.
Stopping Osteoarthritis at the Cellular Level: How Scientists Are Targeting the Body's "Kitchen Disposal" System
Discover how inhibiting the 26S proteasome and K48-linked ubiquitination could revolutionize osteoarthritis treatment by targeting cellular waste management systems.
Breaking Glioblastoma's Shield: Targeting Hidden Weaknesses in Aggressive Brain Cancer
Discover how scientists are targeting the proteasome pathway and DCLK3 kinase to overcome radiation resistance in glioblastoma, the most aggressive brain cancer.
Disaster in the Cancer Cell: Sabotaging the Cell's Emergency Crew
How scientists are exploiting the chaos inside cancer cells by targeting Heat Shock Proteins and the Proteasome to create powerful new treatments.
The Cellular Shredder: How a Hormone Controls the Mailroom of Your Cells
Discover how Angiotensin II regulates cellular communication by sending receptors to the proteasome shredder in this fascinating look at cellular biology.
Unlocking a Cancer's Weakness: The Protein Disposal Dilemma
Discover how Velcade targets cancer cells by inhibiting proteasome function, forcing them into apoptosis through protein waste accumulation.