Research Articles
The Cell's Dark Nucleolus: How a Tiny Tag Drives a Lethal Brain Cancer
Discover how UBE2T-mediated HP1α ubiquitination enhances nucleolar function and drives the progression of IDH1/TP53-mutant glioma in this comprehensive scientific exploration.
F-Box Proteins: The Cellular Guardians Navigating Cancer Immunity
Explore how F-box proteins regulate ubiquitination and influence tumor immunity, with insights into research methods and therapeutic potential.
The Cellular Balancing Act: How MDM2 and ARF Control the Guardian of the Genome
Explore the intricate regulation of p53 tumor suppressor by MDM2 and ARF through ubiquitination and nuclear export mechanisms in cancer biology.
The Ubiquitin Conductor: How Cbl Proteins Direct the Immune System's Symphony
Explore how Cbl proteins regulate immune responses through ubiquitination, their role in macrophage regulation, and therapeutic implications for cancer and autoimmune diseases.
NEDD4 and NEDD4L: The Cellular Conductors Driving Cancer's Destiny
Explore the roles of NEDD4 and NEDD4L proteins as therapeutic targets in lung, prostate, and colorectal cancers through cutting-edge research.
BRCA1's Molecular Scissors: How Targeted Protein Destruction Prevents Cancer
Explore how BRCA1 functions as a ubiquitin ligase, targeting specific proteins for destruction to prevent cancer development through DNA repair mechanisms.
The Cellular Double Agent: How COP1 Tags a Tumor Suppressor for Destruction
Discover how COP1 functions as a ubiquitin ligase for PCDH9 ubiquitination and degradation, revealing critical mechanisms in cancer biology and neurological disorders.
RBX1: The Master Puppeteer Behind Triple-Negative Breast Cancer's Deadly Spread
Breakthrough research unveils how RBX1, a molecular machine, drives the aggressive metastasis of triple-negative breast cancer through ubiquitination pathways.
Cellular Bouncers: How MARCH Proteins Protect Us from Viral Invasion
Discover how MARCH proteins act as cellular bouncers, identifying viral invaders and preventing infection through sophisticated molecular mechanisms.
The Cell's Junkyard: How Our Bodies Manage Protein Garbage
Discover how cells create aggresomes to manage misfolded proteins through ubiquitination, microtubule transport, and maintenance mechanisms.