Research Articles
MARCH E3 Ubiquitin Ligases: The Cellular Traffic Controllers in Cancer Development
Explore the role of MARCH E3 ubiquitin ligases as cellular regulators in cancer development and their potential as therapeutic targets.
Unveiling Cellular Secrets: How Scientists Solved the UbcH5b-CNOT4 Protein Puzzle
Discover how NMR spectroscopy and computational docking revealed the structure of the UbcH5b-CNOT4 ubiquitination complex, advancing our understanding of cellular regulation.
The Cellular Tug-of-War: How RNF149 Regulates Cell Proliferation
Discover how RNF149 regulates cell proliferation by polyubiquitinating CD9, a key mechanism with implications for cancer research.
Stopping Osteoarthritis at the Cellular Level: How Scientists Are Targeting the Body's "Kitchen Disposal" System
Discover how inhibiting the 26S proteasome and K48-linked ubiquitination could revolutionize osteoarthritis treatment by targeting cellular waste management systems.
The Cellular Double Agent: How Flipping a Cancer "Shield" into a "Kill Signal" Offers New Hope
Discover how scientists are turning the SUMO1 cancer protein shield into a kill signal using PROTAC degraders, offering new hope for cancer treatment.
The Ubiquitin Architects: How TRIM Proteins Shape Metabolic Health
Discover how TRIM proteins function as cellular regulators influencing insulin resistance and metabolic disorders through ubiquitination pathways.
The Unseen Battle Within: How a Cellular Conductor Orchestrates Heart Inflammation
Discover how the E3 ubiquitin ligase COP1 regulates macrophage inflammation in sepsis-induced myocardial injury through ubiquitination of C/EBPβ.
The Cellular Switch: How Nedd4 Controls Muscle Fate by Targeting Notch1
Discover how Nedd4 regulates Notch1 in muscle atrophy and its implications for cellular biology and therapeutic development.
The Hidden Factory Within: How Scientists Discovered a Cellular Control System Operating Inside Mitochondria
Discover how scientists found ubiquitination occurring inside mitochondria, rewriting our understanding of cellular control systems.
The Ubiquitin Code: How a Tiny Protein Dictates Wound Healing
Discover how ubiquitin, a tiny protein, regulates the complex process of wound healing through ubiquitination, acting as a cellular maestro in tissue repair and regeneration.