Research Articles
The BRCA1 Ubiquitin Ligase: The Cellular Guardian That Marks Proteins for Destiny
Explore how BRCA1 functions as a ubiquitin ligase enzyme, identifying its key substrates and understanding its crucial role in maintaining cellular health and preventing cancer.
The Cancer Engine: How a Vicious Metabolic Cycle Drives Tumor Aggressiveness
Discover how the GLS1-c-Myc positive feedback loop drives cancer progression and new therapeutic strategies to break this vicious cycle.
The SUMO System: How a Tiny Molecular Guardian Protects Our DNA During Cellular Stress
Discover how SUMO proteins and SUMO-interacting motifs protect our DNA during replication stress and maintain genomic stability.
Shattering Cancer's Shield: The Revolutionary Bispecific Antibodies That Degrade c-MET in NSCLC
Discover how c-MET degrading bispecific antibodies (EpiTACs) are revolutionizing treatment for NSCLC and other c-MET driven tumors through targeted protein degradation.
The Secret Molecular Language of Peach Leaves: How Protein Ubiquitination Shapes Your Favorite Fruit
Discover how ubiquitination, nature's molecular tagging system, influences peach physiology from sugar metabolism to stress response through proteome-wide analysis.
Cecile Pickart: The Maestro of Ubiquitin and Cellular Symphony
Explore the groundbreaking work of Cecile Pickart, who decoded the language of ubiquitin and revolutionized our understanding of cellular regulation.
The Pear's Secret Code: Finding the Constant in a Changing Fruit
Discover how scientists systematically validate reference genes to ensure accurate gene expression studies in pears, from sweetness to disease resistance.
The Cellular Key: How Protein Degradation Unlocks Plant Root Development
Discover how APC-targeted RAA1 degradation regulates cell cycle progression and root architecture in plants through the ubiquitin-proteasome system.
The Genetic Detectives: How Querétaro Scientists Are Unraveling the Mystery of Cleft Lip and Palate
Discover how Querétaro researchers are validating IRF6 and SUMO1 as genetic markers for non-syndromic cleft lip and palate in the local population.
The Hidden Guardian: How a Tiny Protein Could Revolutionize Brain Cancer Treatment
Discover how FBXO8, a tiny protein, correlates with tumor grade and prognosis in human glioma, offering new hope for brain cancer treatment.