Research Articles
Unlocking Protein Secrets in Stone: How Solid-State NMR Peers Into Cellular Fortresses
Explore how Solid-State NMR spectroscopy reveals atomic-level details of crystalline, membrane-embedded, and fibrillar proteins that are inaccessible to other techniques.
The Ubiquitin Code: How Molecular "Orchestrators" Shape Cotton's Fiber and Survival
Discover how RING-H2 finger E3 ligases regulate cotton fiber development and stress responses through genome-wide analysis of Gossypium species.
The Betrayal Within: How Activin Hijacks Cellular Defenses to Fuel Colon Cancer's Spread
Discover how colon cancer cells manipulate the p21 pathway through Activin, PI3K, NF-κB and MDM2 to promote metastasis.
The Proteasome's Achilles' Heel: How Targeting RPN13 Could Revolutionize Ovarian Cancer Treatment
Exploring RPN13 as a novel therapeutic target for ovarian cancer treatment, focusing on its role in the proteasome system and potential to overcome chemotherapy resistance.
The Secret Weapon Inside Salt-Tolerant Plants: How Ubiquitin Warriors Battle Salinity
Discover how ubiquitin-like modifiers help plants survive salt stress through protein recycling, signaling, and autophagy mechanisms.
The Silent Conductors: How TRAF3 and TRAF5 Orchestrate Our Immune Symphony
Exploring the crucial roles of TRAF3 and TRAF5 proteins in immune system regulation and their implications for disease treatment.
Hijacking the Cell's Recycling System: The Revolutionary Science of Targeted Protein Degradation
Explore the groundbreaking science of targeted protein degradation (TPD), a revolutionary strategy that hijacks the cell's natural disposal systems to eliminate disease-causing proteins.
The VHL Hijack: How a Broken Cellular Cleanup Crew Fuels Kidney Cancer—and How Science Is Fighting Back
Exploring how VHL protein dysfunction drives kidney cancer and the innovative therapies targeting this pathway.
The Ubiquitin Assassins: How SCF E3 Ligases Became Cancer's Most Wanted Targets
Exploring how SCF E3 ubiquitin ligases function in cancer and the therapeutic strategies targeting these molecular complexes.
The DOT1L Destroyer: How a Molecular Pac-Man Could Revolutionize Leukemia Treatment
Discover how the first-in-class DOT1L PROTAC degrader MS2133 could revolutionize treatment for MLL-rearranged leukemia by completely eliminating the cancer-causing protein.