Research Articles
NEDD4 and NEDD4L: The Cellular Conductors Driving Cancer's Destiny
Explore the roles of NEDD4 and NEDD4L proteins as therapeutic targets in lung, prostate, and colorectal cancers through cutting-edge research.
Breaking the Cycle: How Cyclin-Dependent Kinases Power Cancer and the Inhibitors Stopping Them
Explore the science behind cyclin-dependent kinases (CDKs), their role in cancer progression, and the breakthrough inhibitors revolutionizing cancer treatment.
The Tiny Molecule That Could Revolutionize Childhood Eye Cancer Treatment
Discover how miR-218-5p acts as a powerful tumor suppressor in retinoblastoma by targeting NACC1 and inhibiting the AKT/mTOR signaling pathway.
Ubiquitin-Specific Peptidase 37: The Master Orchestrator of Cancer Cells
Explore the role of Ubiquitin-Specific Peptidase 37 (USP37) in cancer development, metastasis, and its potential as a therapeutic target.
The Cellular Life-or-Death Switch: How Scientists Are Hijacking Cell Death to Fight Cancer
Explore how cIAP2 functions as a K63 ubiquitin ligase for RIP1 and how IAP BIR antagonists can trigger cancer cell death through programmed apoptosis pathways.
Proteasome Inhibition: A New Frontier in Medulloblastoma Treatment
Exploring the role and clinical implications of proteasome inhibition in medulloblastoma, a devastating childhood brain tumor.
A One-Two Punch for Leukemia: How a New Drug Combo Exploits Cancer's Weakness
Discover how pevonedistat and belinostat work synergistically to combat Acute Myeloid Leukemia by disrupting DNA repair mechanisms and triggering cancer cell death.
BRCA1's Molecular Scissors: How Targeted Protein Destruction Prevents Cancer
Explore how BRCA1 functions as a ubiquitin ligase, targeting specific proteins for destruction to prevent cancer development through DNA repair mechanisms.
The Unlikely Betrayal: How a DNA Repairman Helps Deactivate a Cancer-Fighting Hero
Discover how XPC protein collaborates with MDM2 to degrade p53 tumor suppressor, revealing new insights into cancer mechanisms and potential therapies.
The Music of Our Genes: How Transcriptional Regulation Shapes Cancer and Metabolic Diseases
Explore how transcriptional regulation controls gene expression and its crucial role in cancer and metabolic diseases. Learn about groundbreaking research and future therapeutic approaches.