Research Articles
Trapping the Enemy Within: How Nuclear Export Blockade is Revolutionizing Multiple Myeloma Treatment
Exploring the synergistic effects of selinexor and carfilzomib in targeting XPO1/CRM1-dependent nuclear export to induce apoptosis and autophagy in multiple myeloma.
Flickin' the Ubiquitin Switch: How a Tiny Protein Orchestrates Life's Symphony
Explore how ubiquitin, a small regulatory protein, controls cellular processes through precise molecular switches in DNA repair, immune responses, and gene expression.
The Dance of Destruction: How Protein Engineering Revealed Ubiquitin Ligase Flexibility
Exploring how protein engineering revealed the conformational flexibility of ubiquitin ligases in the ubiquitination process.
The Great Potato Heist: How a Plant Pathogen Hijacks the Immune System's Alarm System
Discover how Phytophthora's RXLR effector Pi18609 sabotages potato immunity by targeting the StBBX27 transcription factor, and learn about potential solutions for blight-resistant crops.
The Invisible Shield: How ISGylation Fights Viral Invaders
Discover how ISGylation, a crucial post-translational modification, serves as your body's frontline defense against viral infections and how pathogens try to evade it.
The PEST Control Paradox: How a Tiny Protein Sequence Holds the Key to Cancer Therapy
Exploring how PEST sequences in nuclear proteins like PCNP regulate cancer progression and the therapeutic potential of targeting these mechanisms.
The RNF43 Enigma: How a Tiny Gene Lights Up Colon Cancer's Dark Pathway
Exploring the critical role of RNF43 mutations in serrated colorectal neoplasia and their implications for cancer treatment.
The Double-Edged Sword: How TRIM27 Shapes Our Health and Fuels Disease
Exploring the dual roles of TRIM27 in cancer, neurodegeneration, and immunity through its ubiquitination mechanisms.
The Ubiquitin Maestro: How the SCF Complex Conducts Life's First Moments
Exploring how the SCF ubiquitin-ligase complex orchestrates protein degradation during gametogenesis, fertilization, and early embryonic development.
The Genomic Jigsaw: Decoding Glioblastoma's Core and Periphery
Exploring the genetic differences between glioblastoma's contrast-enhancing tumor core and infiltrative periphery that drive treatment resistance.