Research Articles
Unlocking HIV's Hideout: How the Viral Protein Vpr Reshapes Epigenetics to Reignite Infection
Discover how HIV's Vpr protein hijacks host epigenetics to reactivate latent viral reservoirs, with implications for cure strategies.
The Ubiquitin Switches: How F-Box Proteins Fuel Cancer's Drug Defenses
Exploring how F-box proteins drive cancer drug resistance through ubiquitin-proteasome system manipulation and potential therapeutic strategies.
The Invisible Architect of Vision: How Ubiquitin Shapes Eye Health and Disease
Explore how the ubiquitin-proteasome system regulates ocular health and contributes to diseases like cataracts, glaucoma, and macular degeneration.
The Ubiquitin Saboteur: How a Mutant Protein Hijacks Cellular Cleanup in Neurodegeneration
Exploring how mutant UBB+1 protein hijacks cellular cleanup mechanisms in neurodegenerative diseases by targeting deubiquitinating enzymes (DUBs)
Decoding Life's Blueprint: How Computers Revolutionized Our Reading of DNA
Exploring how computational approaches transformed next-generation sequencing data into biological insights, with a focus on the Human Cell Atlas project.
Molecular Scissors That Reshaped Biology: How FAK-Targeting PROTACs Revealed Hidden Functions of a Key Protein
Discover how PROTAC technology revolutionized our understanding of FAK protein's non-enzymatic functions in fertility and cancer research.
Acetyl Code Unlocked: How a Molecular Switch Turns ZEB1 Into a Cancer Metastasis Machine
Breakthrough research reveals how K811 acetylation transforms ZEB1 into a lethal driver of lung cancer metastasis through protein stabilization and NuRD complex recruitment.
The miR-16 Enigma: How a Tiny Molecule Exposes a Rare Bone Cancer's Secrets
Discover how miR-16, a small molecule, reveals early signs of Paget's-associated osteosarcoma and could transform cancer diagnosis.
Molecular Staples: The Tiny Technology Taking Aim at Cancer's Command Center
Exploring how stapled alpha-helical peptides disrupt LUBAC to combat cancer by targeting the ubiquitin system.
The Bodyguard and the Conductor: How USP10 Protects BAZ1A to Fuel Head and Neck Cancer's Deadly Resilience
Discover how the USP10-BAZ1A axis drives tumor stemness and therapy resistance in head and neck squamous cell carcinoma through epigenetic mechanisms.