Research Articles
BAP1 Syndrome: The Genetic Mystery Linking Multiple Cancers
Comprehensive overview of BAP1 hereditary cancer predisposition syndrome, its genetics, clinical manifestations, and emerging treatments.
The Cellular Clean-Up Crew: How Rpn1 and Bag-1 Team Up to Fight Cancer
Discover how the Rpn1 and Bag-1 protein complex functions as cellular waste management and its implications for cancer treatment.
The Double-Agent in Our Cells: How RBBP6 Plays Both Sides in the Fight Against Cancer
Discover how RBBP6 protein acts as both cancer suppressor and promoter, its role in breast and cervical cancer, and potential therapeutic applications.
The Cell Cycle's Molecular Timekeeper: How RAP80 Degradation Prevents Cancer
Discover how RAP80 degradation regulated by Cdc20 and Cdh1 ubiquitin ligases prevents cancer through cell cycle control.
The Unlikely Villain: How a Cellular Librarian Goes Rogue to Drive Cancer
Discover how UHRF1 protein drives cancer progression in RB-mediated cancers through epigenetic mechanisms and experimental evidence
Nature's Hidden Weapon: How Plant Compounds Called Polyphyllins Are Revolutionizing Cancer Research
Discover how polyphyllins, natural compounds from Paris plants, are fighting cancer through multiple mechanisms including apoptosis, autophagy, and mitophagy.
Gankyrin: The Cellular Master Regulator Fueling Digestive System Cancers
Explore the role of Gankyrin as a master cellular regulator and its connection to digestive system cancers through molecular mechanisms and therapeutic strategies.
The Proteasome Paradox: A New Way to Sabotage a Cell's Recycling Plant
Scientists discover the first molecules that don't just block—they break—a crucial cellular machine, opening a new front in the fight against cancer.
The Cell's Double Agent: How a Stress Protein Switches Sides to Fight Cancer
Discover how the stress protein ATF3 acts as a molecular double agent, stabilizing p53 by competing with MDM2 to fight cancer development.
NRF3: The Dark Horse of Cancer Biology and Its Unconventional Attack on Tumor Suppressors
Explore how NRF3, a transcription factor, promotes cancer progression by hijacking the proteasomal system to eliminate tumor suppressors like p53 and Rb.