Research Articles
MARCH E3 Ubiquitin Ligases: The Cellular Traffic Controllers in Cancer Development
Explore the role of MARCH E3 ubiquitin ligases as cellular regulators in cancer development and their potential as therapeutic targets.
Cellular "Janitors" & "Assassins": How the Ubiquitin-Proteasome System Became a New Anti-Cancer Weapon
Explore how the ubiquitin-proteasome system, the cell's protein degradation machinery, is being targeted for innovative cancer therapies like proteasome inhibitors and PROTACs.
Disarming Cancer's Shield: How Redox Biology is Revolutionizing Chemotherapy
Discover how redox-based inhibition of MGMT is overcoming chemotherapy resistance in cancer treatment through innovative biological approaches.
The COPS6 Gene: Unlocking New Avenues for Cancer Treatment
Explore the role of COPS6 gene in cancer progression, immune evasion, and its potential as a therapeutic target across multiple tumor types.
The Cell's Guardian: Unmasking a New Weapon in the Fight Against Cancer
Discover how FBW7 protein acts as a cellular guardian by targeting SOX9 for degradation, triggering DNA damage response and S-phase arrest in cancer research.
Friend or Foe: The Dual Nature of UCHL3 in Cancer and the Quest to Tame It
Exploring UCHL3's paradoxical roles in cancer development and the latest research on targeted inhibitor therapies.
Decoding the DNA Guardian: How a Tiny Domain in FANCD2 Helps Prevent Cancer
Explore how the CUE domain in FANCD2 protein acts as a master regulator in DNA repair and its implications for cancer prevention.
Cellular Bouncers: How Ubiquitin Ligases Control the Wnt Nightclub in Cancer
Explore how ubiquitin-dependent mechanisms control Wnt receptors in cancer development, focusing on RNF43 and ZNRF3 as key regulators in tumorigenesis.
The Unlikely Guardian: How a Cellular Enzyme Switches Sides to Protect Us From Cancer
Discover how the Otub1 enzyme stabilizes p53 through monoubiquitination, revealing a novel cancer protection mechanism
The Cellular Saboteur: How a Rogue Protein Drives Cancer's Genetic Chaos
Discover how the CHD1L protein disrupts cell division, causing chromosome missegregation and driving cancer development through a novel molecular pathway.