Research Articles
The PMEPA1-NEDD4 Switch: How Prostate Cancer Cells Hijack Their Off Button
Discover how prostate cancer disables the PMEPA1-NEDD4 molecular brake system that regulates androgen receptor stability, leading to treatment resistance.
The Hidden Code at the Beginning: Unlocking the Secrets of N-Terminal Ubiquitination
Exploring the emerging role of N-terminal ubiquitination in cellular regulation, its mechanisms, biological significance, and research tools.
Pevonedistat: Unlocking Cellular Chaos to Combat T-Cell Lymphoma
Exploring how pevonedistat induces anaphase catastrophe and apoptosis in T-cell lymphoma by inhibiting NEDD8-activating enzyme (NAE).
The Genetic Scalpel: How RNA Interference Is Revolutionizing the Fight Against a Deadly Sheep Parasite
Exploring how RNA interference is being used to target essential genes in Haemonchus contortus, the barber's pole worm, to combat drug resistance in livestock parasites.
The Ubiquitin Maestro: How the SCF Complex Conducts Life's First Moments
Exploring how the SCF ubiquitin-ligase complex orchestrates protein degradation during gametogenesis, fertilization, and early embryonic development.
The Great Potato Heist: How a Plant Pathogen Hijacks the Immune System's Alarm System
Discover how Phytophthora's RXLR effector Pi18609 sabotages potato immunity by targeting the StBBX27 transcription factor, and learn about potential solutions for blight-resistant crops.
The Invisible Shield: How ISGylation Fights Viral Invaders
Discover how ISGylation, a crucial post-translational modification, serves as your body's frontline defense against viral infections and how pathogens try to evade it.
The Double-Edged Sword: How TRIM27 Shapes Our Health and Fuels Disease
Exploring the dual roles of TRIM27 in cancer, neurodegeneration, and immunity through its ubiquitination mechanisms.
The RNF43 Enigma: How a Tiny Gene Lights Up Colon Cancer's Dark Pathway
Exploring the critical role of RNF43 mutations in serrated colorectal neoplasia and their implications for cancer treatment.
The PEST Control Paradox: How a Tiny Protein Sequence Holds the Key to Cancer Therapy
Exploring how PEST sequences in nuclear proteins like PCNP regulate cancer progression and the therapeutic potential of targeting these mechanisms.