Research Articles
The Dance of Destruction: How Protein Engineering Revealed Ubiquitin Ligase Flexibility
Exploring how protein engineering revealed the conformational flexibility of ubiquitin ligases in the ubiquitination process.
Flickin' the Ubiquitin Switch: How a Tiny Protein Orchestrates Life's Symphony
Explore how ubiquitin, a small regulatory protein, controls cellular processes through precise molecular switches in DNA repair, immune responses, and gene expression.
The Bodyguard and the Conductor: How USP10 Protects BAZ1A to Fuel Head and Neck Cancer's Deadly Resilience
Discover how the USP10-BAZ1A axis drives tumor stemness and therapy resistance in head and neck squamous cell carcinoma through epigenetic mechanisms.
Trapping the Enemy Within: How Nuclear Export Blockade is Revolutionizing Multiple Myeloma Treatment
Exploring the synergistic effects of selinexor and carfilzomib in targeting XPO1/CRM1-dependent nuclear export to induce apoptosis and autophagy in multiple myeloma.
The miR-16 Enigma: How a Tiny Molecule Exposes a Rare Bone Cancer's Secrets
Discover how miR-16, a small molecule, reveals early signs of Paget's-associated osteosarcoma and could transform cancer diagnosis.
Molecular Staples: The Tiny Technology Taking Aim at Cancer's Command Center
Exploring how stapled alpha-helical peptides disrupt LUBAC to combat cancer by targeting the ubiquitin system.
Acetyl Code Unlocked: How a Molecular Switch Turns ZEB1 Into a Cancer Metastasis Machine
Breakthrough research reveals how K811 acetylation transforms ZEB1 into a lethal driver of lung cancer metastasis through protein stabilization and NuRD complex recruitment.
Decoding Life's Blueprint: How Computers Revolutionized Our Reading of DNA
Exploring how computational approaches transformed next-generation sequencing data into biological insights, with a focus on the Human Cell Atlas project.
Molecular Scissors That Reshaped Biology: How FAK-Targeting PROTACs Revealed Hidden Functions of a Key Protein
Discover how PROTAC technology revolutionized our understanding of FAK protein's non-enzymatic functions in fertility and cancer research.
The Ubiquitin Saboteur: How a Mutant Protein Hijacks Cellular Cleanup in Neurodegeneration
Exploring how mutant UBB+1 protein hijacks cellular cleanup mechanisms in neurodegenerative diseases by targeting deubiquitinating enzymes (DUBs)