Research Articles
K48 vs K63 Polyubiquitination: Decoding the Functional Dichotomy in Cell Signaling, Disease, and Drug Discovery
This review provides a comprehensive, up-to-date analysis of K48-linked and K63-linked polyubiquitin chains, the two most prevalent and functionally distinct ubiquitin modifications.
Decoding the Ubiquitin Code: K48 vs K63 Polyubiquitination in Cellular Signaling and Disease
This article provides a comprehensive analysis of K48- and K63-linked polyubiquitin chains, two pivotal post-translational modifications with opposing cellular functions.
K48 vs K63 Polyubiquitin Chains in Proteasomal Degradation: Mechanisms, Methods, and Therapeutic Implications
This article provides a comprehensive analysis of K48-linked versus K63-linked polyubiquitin chains in the context of proteasome-mediated degradation.
K48 vs K63 Ubiquitin Chains: Decoding Their Divergent Roles in DNA Damage Repair Pathways
This article provides a comprehensive analysis of the distinct functions of K48-linked and K63-linked polyubiquitin chains in the cellular DNA damage response (DDR).
K-ε-GG Antibody Enrichment Protocol: A Complete Guide to Mass Spectrometry-Based Ubiquitinome Profiling
This comprehensive guide details the K-ε-GG antibody enrichment protocol, the gold-standard method for isolating and identifying protein ubiquitination sites via mass spectrometry.
K-ε-GG Antibody Enrichment for Ubiquitin Remnant Profiling: A Comprehensive Guide for Proteomics Research and Drug Discovery
This article provides a detailed guide to K-ε-GG antibody enrichment, a critical technique in ubiquitin remnant profiling for studying the ubiquitin-proteasome system.
The 1977 Discovery: How Etlinger & Goldberg's Reticulocyte System Unlocked Ubiquitin-Proteasome Protein Degradation
This article comprehensively explores the seminal 1977 work of Joseph Etlinger and Alfred Goldberg on ATP-dependent protein degradation in rabbit reticulocytes.
Enhancing Specificity in Endogenous Ubiquitin IP: A Complete Guide for Reliable Proteomic Analysis
This article provides a comprehensive guide for researchers aiming to improve the specificity and reliability of endogenous ubiquitin immunoprecipitation (IP) experiments.
Mastering Linkage-Specific Ubiquitin IHC on FFPE Tissue: A Complete Protocol for Research & Drug Development
This comprehensive guide details an optimized immunohistochemistry (IHC) protocol for detecting specific ubiquitin chain linkages (e.g., K48, K63, M1) in formalin-fixed paraffin-embedded (FFPE) tissues.
TUBEs in Ubiquitin Research: A Complete Guide to Endogenous Protein Isolation, Detection, and Analysis
This comprehensive guide provides researchers and drug development scientists with a detailed exploration of Tandem Ubiquitin Binding Entities (TUBEs) for studying endogenous ubiquitin signaling.