Research Articles
Ubiquitin's Double-Edged Sword: Orchestrating DNA Repair and Driving Cancer
This article explores the critical and dualistic role of the ubiquitin-proteasome system (UPS) in the DNA damage response (DDR) and cancer pathogenesis.
Ubiquitylomics in Cancer Research: Comprehensive Analysis of Ubiquitination Landscapes in Malignant vs Normal Tissues
This article provides a comprehensive examination of ubiquitylomics—the large-scale study of protein ubiquitination—in the context of cancer biology and therapeutic development.
Mapping the Ubiquitinome: Advanced Strategies for Identifying Ubiquitination Substrates in Tumor Samples
The identification of ubiquitination substrates in tumor samples is a critical frontier in cancer research, holding immense potential for understanding tumor biology, developing prognostic biomarkers, and discovering new therapeutic targets.
Decoding the Ubiquitin Code in Cancer: Mechanisms, Therapeutic Targeting, and Clinical Frontiers
The ubiquitin code, a complex system of post-translational modifications, is fundamentally altered in cancer, driving tumorigenesis through dysregulated protein stability, signaling, and cellular homeostasis.
E3 Ubiquitin Ligase Mutations in Human Cancers: Mechanisms, Therapeutic Targeting, and Clinical Implications
This review synthesizes current knowledge on the critical role of E3 ubiquitin ligase mutations in human carcinogenesis.
Ubiquitination in Cancer Stem Cell Maintenance: Molecular Mechanisms and Therapeutic Targeting
This article comprehensively examines the critical role of the ubiquitin-proteasome system (UPS) in regulating cancer stem cell (CSC) maintenance, a key driver of tumor progression, metastasis, and therapy resistance.
Ubiquitin Signaling in the Tumor Microenvironment: Mechanisms, Therapeutic Targeting, and Clinical Frontiers
This article provides a comprehensive analysis of the ubiquitin signaling network's critical role in shaping the tumor microenvironment (TME).
Ubiquitination Patterns in Cancer: From Molecular Mechanisms to Clinical Applications in Biomarker and Therapy Development
This comprehensive review synthesizes current research on dysregulated ubiquitination patterns in cancer versus normal tissues, exploring their profound implications for tumor biology and clinical practice.
Ubiquitination in Cancer Metabolic Reprogramming: Mechanisms, Therapeutic Targeting, and Clinical Challenges
Cancer cells undergo profound metabolic reprogramming to support rapid proliferation and survival, characterized by alterations in glucose, lipid, and amino acid metabolism.
Deubiquitinating Enzymes (DUBs) in Cancer: Mechanisms, Therapeutic Targeting, and Future Directions
This comprehensive review elucidates the critical functions of deubiquitinating enzymes (DUBs) in oncogenesis and cancer progression.