Research Articles
Deubiquitinating Enzymes: The Cellular "Undo" Button Revolutionizing Cancer Treatment
Explore how deubiquitinating enzymes (DUBs) are emerging as promising targets for novel cancer therapies through their role in protein regulation and cellular fate determination.
Targeting the MYC Pathway: New Hope for Pancreatic Cancer Treatment
Exploring innovative strategies to target the MYC oncogene for pancreatic cancer treatment, including indirect inhibition, mRNA degradation, and combination therapies.
Breaking the Shield: How SIK2 Inhibitor SIC-19 Makes Resistant Cancers Vulnerable to PARP Inhibitors
Discover how SIK2 inhibitor SIC-19 enhances PARP inhibitor sensitivity in triple-negative breast and pancreatic cancers through synthetic lethality approach.
Destroying the Puppeteer: How Targeting UHRF1's Destruction Offers New Hope for Small Cell Lung Cancer
Exploring how exploiting UHRF1's natural degradation pathway offers a promising new therapeutic strategy for small cell lung cancer patients.
HAUSP Hunting: How Scientists Are Disarming Cancer's Master Switch
Explore the groundbreaking research on USP7 inhibitors as a promising cancer therapy targeting protein stability and immune response activation.
How Stopping a Cellular Enzyme Could Revolutionize Cancer Treatment
Discover how GSK-3 inhibition affects DNA damage response through TopBP1 degradation and its potential for revolutionizing cancer therapy.
Breaking the Cycle: How Targeting Two Cellular Enzymes Offers New Hope for Waldenström's Macroglobulinemia Patients
Discover how targeting USP14 and UCHL5 enzymes offers breakthrough potential for treating Waldenström's Macroglobulinemia, a rare blood cancer.
The Ubiquitin-Proteasome System as a Prospective Molecular Target for Cancer Treatment and Prevention
Explore how the ubiquitin-proteasome system, our cellular recycling machinery, is being targeted for innovative cancer therapies and prevention strategies.
P97: The Achilles' Heel of Cancer—How Targeting a Single Protein Could Revolutionize Cancer Treatment
Discover how targeting the p97 protein could revolutionize cancer treatment by eliminating cancer stem cells and overcoming treatment resistance.
The Molecular Wrench: How Lenalidomide Hijacks Cancer's Own Machinery
Discover how lenalidomide works as a molecular glue to hijack cancer's cellular machinery and treat multiple myeloma through targeted protein degradation.