Research Articles
The SMURF2 Gene: How an Epigenetic Switch May Guide Multiple Myeloma Progression
Explore the connection between SMURF2 methylation and clinical outcomes in multiple myeloma patients, examining how epigenetic regulation influences disease progression.
How a Plant-Derived Compound Fights Blood Cancer: The Flavopiridol Story
Explore how Flavopiridol, a plant-derived compound, induces apoptosis in multiple myeloma cells through transcriptional repression and Mcl-1 down-regulation.
Protein Destroyers: How BRD4-Targeting PROTACs Are Revolutionizing Cancer Therapy
Explore how BRD4-targeting PROTACs are transforming multiple myeloma treatment through targeted protein degradation technology.
Targeting Cancer's Cellular Garbage Disposal: The Promise of p97 Inhibitor CB-5083 in Multiple Myeloma
Explore the groundbreaking pre-clinical research on CB-5083, a novel p97 inhibitor showing significant promise in treating multiple myeloma by targeting cancer cells' protein disposal systems.
The Molecular Wrench: How Lenalidomide Hijacks Cancer's Own Machinery
Discover how lenalidomide works as a molecular glue to hijack cancer's cellular machinery and treat multiple myeloma through targeted protein degradation.
The RFWD2 Puzzle: How a Cellular Ubiquitin Ligase Drives Cancer Growth and Drug Resistance
Exploring how RFWD2, an E3 ubiquitin ligase, drives multiple myeloma progression and proteasome inhibitor resistance through P27 degradation.
MicroRNA: The Tiny Conductor of Myeloma's Fate
Explore how microRNA expression patterns predict bortezomib response in multiple myeloma patients, ushering in personalized cancer treatment.
The TRIM44 Enigma: How a Tiny Protein Fuels Multiple Myeloma's Deadly Resistance
Exploring TRIM44's role as a prognostic biomarker and therapeutic target in proteasome-resistant multiple myeloma