Research Articles
Marine Molecule to Cancer Fighter: The Promise of Metal-Based Isatin Derivatives
Explore how metal-based isatin derivatives from marine organisms are emerging as powerful proteasome inhibitors and apoptosis inducers in human cancer cells.
The Cellular Stress Manager: Unlocking the Secrets of the JNK Pathway
Explore the JNK pathway - a crucial cellular signaling system that determines cell fate in response to stress, with implications for cancer, neurodegenerative diseases, and viral infections.
The TAp73 Enigma: How a Cellular Guardian Switches Sides in the Face of Lethal Stress
Discover the dual nature of TAp73 protein in cellular stress response and its implications for cancer therapy.
Cellular Guardians and Traitors: The Double Life of Apoptosis-Inhibiting Proteins
Explore the fascinating world of Inhibitor of Apoptosis Proteins (IAPs) - crucial regulators of cell death, inflammation, and cancer progression.
The Cellular Life-or-Death Switch: How Scientists Are Hijacking Cell Death to Fight Cancer
Explore how cIAP2 functions as a K63 ubiquitin ligase for RIP1 and how IAP BIR antagonists can trigger cancer cell death through programmed apoptosis pathways.
How a Plant-Derived Compound Fights Blood Cancer: The Flavopiridol Story
Explore how Flavopiridol, a plant-derived compound, induces apoptosis in multiple myeloma cells through transcriptional repression and Mcl-1 down-regulation.
The Double-Agent in Our Cells: How RBBP6 Plays Both Sides in the Fight Against Cancer
Discover how RBBP6 protein acts as both cancer suppressor and promoter, its role in breast and cervical cancer, and potential therapeutic applications.
A Botanical Assassin: How an Ancient Herb Tricks Cancer Cells into Self-Destructing
Discover how Oridonin from traditional Chinese medicine induces apoptosis in neuroblastoma cells by promoting Mdm2-p60 and activating p53-mediated pathways.
Unlocking a Cancer's Weakness: The Protein Disposal Dilemma
Discover how Velcade targets cancer cells by inhibiting proteasome function, forcing them into apoptosis through protein waste accumulation.
Breaking the Shield: How a Novel Compound Forces Lung Cancer Cells to Self-Destruct
Discover how SHetA2 overcomes lung cancer resistance by down-regulating c-FLIP and survivin to enhance TRAIL-induced apoptosis.