Research Articles
A Sweet Trap for Rogue Cancer Cells: Starving Tumors of Sugar Triggers Self-Destruction
Discover how glucose restriction induces degradation of mutant p53 proteins via selective autophagy, offering new cancer therapy approaches.
Marine Molecule to Cancer Fighter: The Promise of Metal-Based Isatin Derivatives
Explore how metal-based isatin derivatives from marine organisms are emerging as powerful proteasome inhibitors and apoptosis inducers in human cancer cells.
A One-Two Punch for Cancer: How a New Drug Combination Disarms a Key Survival Protein
Discover how a novel drug combination targets cancer by disarming the c-MET and EGFR proteins through enhanced degradation via the ubiquitin/proteasome pathway.
Taming the Rogue Engineer: How a New Approach Could Thwart a Common Cancer Driver
Discover how inhibiting the PI3K/Akt pathway could disarm the c-Myb oncogene, offering new hope for cancer treatment strategies.
The Cellular Betrayal: How a Rogue Protein Fuels Cancer's Spread
Discover how the MSK1 protein stabilizes Snail through USP5-mediated deubiquitination, driving colorectal cancer metastasis.
Disarming Cancer's Shield: How a Cellular "Saboteur" Helps Tumors Hide
Discover how the ATXN3 protein regulates PD-L1 in cancer cells and enables tumor immune evasion through CRISPR screening research.
The Silent Thief: Unraveling the Mystery of Cancer's Weight-Loss Syndrome
How scientists are using gene networks to fight the devastating muscle wasting of pancreatic cancer.
The Invisible Shield: How Cancer Hides from Our Immune System
Discover how cancer evades immune detection through MHC-I pathway manipulation and the breakthrough discovery of a membrane-associated inhibitory axis.
The Unlikely Ally: How Stopping Muscle Waste Could Slow Cancer's Spread
Discover how blocking muscle wasting protein MuRF1 impedes pancreatic tumor growth in this groundbreaking cancer research.
Attacking the Attackers: How a Cellular "Janitor" Helps Cancer Hide
New research reveals how USP24 stabilizes PD-1 protein in T cells, helping cancer evade immune detection and suggesting new therapeutic approaches.