Research Articles
The Cellular Betrayal: How a Rogue Protein Unlocks Cancer's Spread
Discover how VRK2 protein promotes liver cancer metastasis by stabilizing ATG5 and activating autophagy-mediated degradation of ZO-1 tight junctions.
The Silent Hijackers: How Microscopic Parasites Turn Our Cells' Recycling System Against Us
Discover how microsporidia parasites cleverly hijack cellular autophagy to promote their own growth in mammalian cells.
A Sweet Trap for Rogue Cancer Cells: Starving Tumors of Sugar Triggers Self-Destruction
Discover how glucose restriction induces degradation of mutant p53 proteins via selective autophagy, offering new cancer therapy approaches.
ATG7: The Cellular Guardian Between Health and Disease
Explore the dual nature of ATG7 protein - its crucial role in cellular autophagy and its complex relationship with health and disease.
Atg7: The Cellular Guardian That Could Be a Trojan Horse
Exploring the dual nature of Atg7 protein in cellular processes, its role in health and disease, and therapeutic implications.
Nature's Double-Edged Sword: How a New Plant Compound Tricks Cancer Cells into Eating Themselves
Discover how 3′-epi-12β-hydroxyfroside, a novel cardenolide, induces cytoprotective autophagy by blocking the Hsp90/Akt/mTOR axis in lung cancer cells.
Helical Warriors: How Foldable Molecules Are Rewriting Cancer's Playbook
Discover how helical sulfonyl-γ-AApeptides target LC3 in cancer cells to disrupt autophagy and create new cancer therapies.
The Cell's Double-Edged Sword: How a Misfiring Recycling Plant Can Trigger Cell Death
Explore how AAF-cmk targets cellular recycling mechanisms to induce apoptosis, autophagy, and protein aggregation in cancer cells.
To Kill or to Be Killed: How Does the Battle between the UPS and Autophagy Maintain the Intracellular Homeostasis in Eukaryotes?
Explore the intricate battle between the Ubiquitin-Proteasome System (UPS) and autophagy in maintaining cellular homeostasis and preventing diseases.
The ATG8 Enigma: Unifying the Science Behind Cellular Spring Cleaning
Unifying model explaining the versatile roles of ATG8 proteins in autophagy and cellular quality control