Research Articles
Breaking the Cancer Fortress: Targeting the SPHK1/HIF1 Pathway to Eradicate Colorectal Cancer at Its Root
Explore how targeting the SPHK1/HIF1 pathway offers new hope for eliminating colorectal cancer stem cells and overcoming treatment resistance.
The Hidden Highway: How Wnt Signaling Drives Acute Myeloid Leukemia
Explore how the ancient Wnt signaling pathway becomes hijacked in acute myeloid leukemia, fueling cancer stem cells and driving treatment resistance.
The Invisible Enemy: How CD44 and SMURF1 Team Up to Drive Cancer Treatment Resistance
Discover how CD44 and SMURF1 signaling maintains cancer stem cells in head and neck cancer, driving treatment resistance and recurrence.
UCHL1: The Cellular Architect Behind Neuroblastoma's Resilience
Exploring the role of Ubiquitin carboxyl-terminal esterase L1 (UCHL1) in neuroblastoma cancer stem-like cells and its therapeutic implications
P97: The Achilles' Heel of Cancer—How Targeting a Single Protein Could Revolutionize Cancer Treatment
Discover how targeting the p97 protein could revolutionize cancer treatment by eliminating cancer stem cells and overcoming treatment resistance.
The TRIM16 Enigma: How a Cellular Watchdog Tames Breast Cancer's Most Dangerous Cells
Exploring the role of TRIM16 in suppressing breast cancer stem cells through Gli-1 degradation via the ubiquitin-proteasome pathway
The Lipid Linchpin: How a Metabolic Mastermind Fuels Lung Cancer's Deadliest Cells
Exploring how SCD1's manipulation of cellular architecture through YAP/TAZ fuels lung cancer stem cells and drives recurrence.