Research Articles
The Cellular Switch: How Ubiquitin and Molecular Scissors Regulate Your Enzymes
Discover how ubiquitin-fold proteins and JAMM/MPN+ metalloproteases create a sophisticated cellular regulation system that controls enzyme activity through reversible modification.
Reversed Proteolysis: When Protein-Scissors Become Molecular Glue
Explore the fascinating world of reversed proteolysis where proteases function as peptide ligases, creating new possibilities in biochemistry and medicine.
The Case of the Molecular Zombie Enzymes: An Evolutionary Whodunit
Discover how OTU-family de-ubiquitylating enzymes lost their catalytic activity through evolution, becoming molecular zombies with new cellular functions.