Research Articles
Cellular Sabotage: How Viruses Hijack Our Protein Disposal System
Discover how viruses manipulate the ubiquitin pathway to hijack cellular machinery and evade immune defenses in this comprehensive scientific exploration.
The Proteasome: From Cellular Garbage Disposal to Nobel Prize-Winning Breakthrough
Explore the revolutionary discovery of the ubiquitin-proteasome system, its role in cellular regulation, and its implications for treating human diseases.
The Cellular Brake: How a Tiny Worm Reveals Unknown Mechanisms Controlling Cancer-Related Signals
Discover how UFD-2 regulates LIN-45 in C. elegans and its implications for cancer research and cellular signaling pathways.
The Pup-Proteasome System: How Bacteria Play by Eukaryotic Rules
Exploring the sophisticated protein recycling system in bacteria that mirrors eukaryotic cellular machinery and its implications for combating pathogens like tuberculosis.
The Cell's Hitman: How Our Body Marks a Key SARS-CoV-2 Protein for Destruction
Discover how our cells use the CRL4B-PRPF19 complex to target SARS-CoV-2 ORF6 protein for destruction, revealing new antiviral therapeutic strategies.
WWP2: The Master Cellular Regulator You've Never Heard Of
Discover WWP2, a multifunctional ubiquitin ligase that regulates immunity, fibrosis, cancer, and more. Learn about its cellular functions and therapeutic potential.
The Cellular Scissors in Crisis: How a Tiny Molecular Tag Can Make or Break Cancer Treatment
Explore how ubiquitin and SUMO molecular tags regulate topoisomerase II stability and their crucial implications for cancer chemotherapy.
The Accidental Hero: How an Old Arthritis Drug Supercharges a Cellular Cleanup Crew
Discover how Auranofin, an old arthritis drug, enhances UBA1 activity and facilitates ubiquitin trans-thioesterification to E2 enzymes, opening new frontiers in disease treatment.
The UFM1 Enigma: Shedding Light on One of Biology's Most Mysterious Molecular Regulators
Explore the fascinating world of UFM1, one of biology's most mysterious molecular regulators, and discover its crucial role in cellular health and disease prevention.
The RFWD2 Puzzle: How a Cellular Ubiquitin Ligase Drives Cancer Growth and Drug Resistance
Exploring how RFWD2, an E3 ubiquitin ligase, drives multiple myeloma progression and proteasome inhibitor resistance through P27 degradation.