Research Articles
When the Brain's Recycling System Fails: How Proteasome Depletion Triggers Neurodegeneration
Discover how 26S proteasome dysfunction in mouse brain neurons leads to neurodegeneration and Lewy-like inclusions resembling human pale bodies.
Cellular Housekeeping: How New Molecules Could Stop Muscle Waste
Discover how belactosin A and C proteasome inhibitors could revolutionize treatment for muscle wasting diseases through groundbreaking research on rat skeletal muscle.
The Proteasome Paradox: Why Cells Destroy Their Transcription Activators
Exploring the surprising connection between protein destruction and gene activation in cellular regulation
Proteasome Inhibition: A New Frontier in Medulloblastoma Treatment
Exploring the role and clinical implications of proteasome inhibition in medulloblastoma, a devastating childhood brain tumor.
The Proteasome Paradox: A New Way to Sabotage a Cell's Recycling Plant
Scientists discover the first molecules that don't just block—they break—a crucial cellular machine, opening a new front in the fight against cancer.
The Proteasome: From Cellular Garbage Disposal to Nobel Prize-Winning Breakthrough
Explore the revolutionary discovery of the ubiquitin-proteasome system, its role in cellular regulation, and its implications for treating human diseases.
The Stem Cell's Secret Keeper: How a Cellular Cleanup Crew Guards Our Greatest Potential
Discover how the proteasome, a cellular cleanup crew, actively maintains stem cell pluripotency by selectively degrading differentiation factors.
The Cellular Shredder: How a "Quality Control" Glitch Sparks Tumors
Discover how rapid proteasomal degradation of mutant AIP proteins triggers tumor formation in hereditary cancer syndromes.
The Cell's Broken Garbage Disposal: How It Creates Superbugs
Discover how a fault in fission yeast's proteasome creates multi-drug resistant superbugs by stabilizing the Pap1 transcription factor.
The Cell's Garbage Disposal: How Targeting a Tiny Machine is Revolutionizing Medicine
Explore how targeting the proteasome pathway is transforming cancer treatment and opening new frontiers in medicine.