Research Articles
Getting the Upper Hand in ALS: New Research Shifts the Battlefield
Recent breakthroughs in ALS research are fundamentally changing the landscape, giving patients and researchers real, tangible hope through autoimmune discoveries and gene therapies.
Riluzole's Paradox: Why an ALS Drug Failed in a Groundbreaking Rat Model
Exploring the scientific paradox of riluzole's failure in a transgenic TDP-43 rat model despite its proven clinical efficacy in human ALS patients.
Catching a Killer: How Protein Sleuthing Reveals ALS Triggers
Discover how proteogenomics is revolutionizing ALS research by revealing how CCNF gene mutations trigger cell death pathways in motor neurons.
Two Faces of One Disease: The Surprising Connection Between ALS and FTD
Discover the groundbreaking research revealing how ALS and FTD, once thought to be separate conditions, are actually two manifestations of the same underlying disease process.
When Mind and Muscle Fail: The Surprising Connection Between ALS and Frontotemporal Dementia
Exploring the overlapping characteristics of amyotrophic lateral sclerosis and frontotemporal dementia, from genetics to clinical manifestations.
Stopping a Chain Reaction: How Preventing SOD1 Modification Could Combat ALS
Discover how preventing SUMOylation at lysine 75 could inhibit mutant SOD1 aggregation in ALS, offering new therapeutic approaches for this neurodegenerative disease.
The Silent Mutation: How a Tiny Genetic Change Accelerates Motor Neuron Disease
Discover how the OPTN-K489E mutation disrupts cellular balance and accelerates ALS progression through enhanced apoptosis, necroptosis, and autophagy pathways.