Research Articles
Unlocking a Cancer's Weakness: The Protein Disposal Dilemma
Discover how Velcade targets cancer cells by inhibiting proteasome function, forcing them into apoptosis through protein waste accumulation.
Hunting Cancer's Hidden Saboteurs: When Tiny Mutations Re-Wire Our Cellular Engines
Discover how bioinformatic pipelines identify change-of-function mutations that reprogram cancer cell metabolism, opening new avenues for targeted therapies.
Cracking the Cancer Code: How Scientists Are Untangling a Complex Tumor, One Cell at a Time
Discover how single-cell RNA sequencing is revealing the genetic diversity within chordoma tumors and paving the way for targeted cancer therapies.
Disarming the Cell's Master Switch: The High-Tech Hunt for New Cancer Drugs
Explore how scientists use chemoinformatics and high-throughput screening to identify novel USP7 inhibitors for cancer treatment.
Disarming Cancer's Master Switch: How a Molecular Wrench Could Halt Tumors
Explore how mutant EGFR proteins interact with Hsp90 chaperones and how Geldanamycin triggers their degradation in cancer treatment.
Breaking Cancer's Command Center: How Targeting a Tiny Protein Could Defeat Advanced Cancers
Discover how SIAH inhibition creates a major vulnerability in cancers driven by EGFR/HER2/RAS signaling pathways through RPPA kinomic profiling.
The Cancer Engine: How a Vicious Metabolic Cycle Drives Tumor Aggressiveness
Discover how the GLS1-c-Myc positive feedback loop drives cancer progression and new therapeutic strategies to break this vicious cycle.
The Invisible Editors of Cancer: How Ubiquitin-Specific Proteases Rewrite Our Understanding of Tumors
Recent research reveals USPs as master regulators of tumor survival, metastasis, and drug resistance, making them prime targets for next-generation therapies.
Rewriting Cancer's Rules: The Protein-Destroying Therapies Entering Human Trials
Explore the revolutionary protein degradation therapies entering clinical trials for cancer treatment, offering new hope against 'undruggable' targets.
The Lethal Overdrive: How Supercharging Cancer Pathways Could Be Our Smartest Weapon Yet
Exploring how hyperactivating cancer pathways can be a novel synthetic lethality approach in oncology