Research Articles
A Cellular Traffic Cop: How Two Drugs Team Up to Halt a Rogue Cancer
Discover how Imatinib and Bortezomib work together to reactivate the APC/Cdh1 complex in Blast Crisis CML, offering new hope for cancer treatment.
How a Cellular "Bodyguard" Drives a Rare Leukemia
Discover how USP7 protein stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia, creating new therapeutic opportunities for cancer treatment.
Beyond Kinase Inhibition: The Unexpected Role of Ubiquitin in BCR-ABL Leukemogenesis
Exploring how ubiquitin-mediated interactions serve as BCR-ABL's accomplice in leukemogenesis, opening new therapeutic avenues for CML treatment.
Unlocking the Immune System: How a Revolutionary Cancer Drug Fights Leukemia on Two Fronts
Discover how DS-5272 inhibits MLL-fusion leukemia through dual mechanisms: direct p53 activation and immune system engagement.
A One-Two Punch for Leukemia: How a New Drug Combo Exploits Cancer's Weakness
Discover how pevonedistat and belinostat work synergistically to combat Acute Myeloid Leukemia by disrupting DNA repair mechanisms and triggering cancer cell death.
Cellular Switchboards: How Protein Modifications Rewire Leukemia Cells and Silence Tumor Suppressors
Explore how ubiquitin-like modifications and p53 NEDDylation at lysine 120 impact chronic lymphocytic leukemia progression and treatment.
The Molecular Betrayal: How Leukemia Hijacks a Cellular Repair Team
Discover how chronic myeloid leukemia disables cellular repair mechanisms through BAP1-BRCA1 downregulation
A Molecular Trojan Horse: New Hope in the Fight Against Leukemia
Discover how PROTAC molecular technology is revolutionizing leukemia treatment by degrading cancer-causing proteins with unprecedented efficacy.
Disarming the Enemy Within: The New Era of Precision Strikes Against Leukemia
Explore how gene product-targeting therapy is revolutionizing leukemia treatment through precision medicine approaches.
Cellular Hide and Seek: How Leukemia Cells Use Tiny Bubbles to Resist Chemotherapy
Discover how exosomal miR-196a-5p helps acute myeloid leukemia cells resist chemotherapy through ferroptosis inhibition in the bone marrow microenvironment.