Research Articles
The Cellular Balancing Act: How MDM2 and ARF Control the Guardian of the Genome
Explore the intricate regulation of p53 tumor suppressor by MDM2 and ARF through ubiquitination and nuclear export mechanisms in cancer biology.
The Unbreakable Guardian: How p53 Fights Cancer Even When Its Partner is Gone
Discover how p53, the master tumor suppressor, can still fight cancer even when its key partner ATM is missing, revealing cellular resilience and backup defense mechanisms.
The Dark Knight of the Genome: How p53 Acts as Your Cell's Batman
Explore how p53, the guardian of the genome, functions like Batman to control the cell cycle and prevent cancer through an engaging movie plot analogy.
The p53 Orchestra: How Ribosomal Protein S27a Conducts Cellular Defense Against Cancer
Exploring how ribosomal protein S27a regulates p53's tumor suppression activities and its dual role in cancer progression.
Unlocking p53's Potential: The Gene Signature Predicting Cancer Drug Success
Discover how a 13-gene signature predicts response to MDM2 inhibitors in p53 wild-type cancers, enabling personalized therapy approaches.
The p53 Puzzle: Decoding the Guardian's Secrets to Revolutionize Cancer Therapy
Exploring groundbreaking patents and therapies targeting the p53 protein to revolutionize cancer treatment.