Research Articles
Pevonedistat: Unlocking Cellular Chaos to Combat T-Cell Lymphoma
Exploring how pevonedistat induces anaphase catastrophe and apoptosis in T-cell lymphoma by inhibiting NEDD8-activating enzyme (NAE).
The PMEPA1-NEDD4 Switch: How Prostate Cancer Cells Hijack Their Off Button
Discover how prostate cancer disables the PMEPA1-NEDD4 molecular brake system that regulates androgen receptor stability, leading to treatment resistance.
The Hidden Code at the Beginning: Unlocking the Secrets of N-Terminal Ubiquitination
Exploring the emerging role of N-terminal ubiquitination in cellular regulation, its mechanisms, biological significance, and research tools.
USP47: The Enzyme Sculpting Cancer's Deadliest Escape Routes
Exploring the critical role of USP47 in cancer metastasis through epithelial-mesenchymal transition (EMT) and its potential as a therapeutic target.
The Invisible Shield: How HLTF and SHPRH Guard Our Genome Against Cancer
Exploring the roles of HLTF and SHPRH proteins in DNA damage repair and their implications in cancer prevention and treatment.
The Molecular Scissors Fueling Esophageal Cancer: How SENP5 Hijacks Cellular Machinery to Drive Tumor Growth
Discover how SENP5 promotes esophageal squamous cell carcinoma growth through the NF-κB-SLC1A3 axis and its potential as a therapeutic target.
The Mitochondrial Map of Parkinson's Disease: Charting the Landscape of a Scientific Revolution
A comprehensive bibliometric analysis of mitochondrial research in Parkinson's disease, exploring growth trends, key discoveries, and future directions.
Shattering the Undruggable Barrier: How Molecular Matchmakers Are Revolutionizing Medicine
Explore how PROTACs are revolutionizing medicine by targeting previously 'undruggable' proteins for degradation, with clinical breakthroughs in cancer and neurodegenerative diseases.
Decoding Complexity: How Systems Biology is Rewriting the Parkinson's Playbook
Explore how systems biology is transforming Parkinson's disease research through network analysis, multi-omics integration, and novel therapeutic approaches.
Silencing the Storm: How a Bone Drug Halts Prostate Cancer's Stealth Spread
New research reveals how Zoledronic acid dismantles EMT's machinery by targeting NEDD9, silencing prostate cancer's invasive voice.