Research Articles
Chaperone Activators: Cellular Repair Crews and the Drugs That Wake Them Up
Explore how molecular chaperones maintain cellular health and how chaperone activators offer new therapeutic approaches for neurodegenerative diseases, cancer, and aging-related conditions.
The Unsung Heroes of Your Tomato: How Molecular Guardians Shape Your Fruit
Discover how E2 ubiquitin-conjugating enzymes act as molecular guardians in tomatoes, regulating growth, ripening, and disease resistance through genome-wide identification and expression analysis.
The Cell's Master Switch: How Ras GTPases Command Our Biology
Explore the fascinating world of Ras GTPases and their interaction with effector domains - the molecular switches that control cell growth and cancer development.
Cellular Traffic Control: The Surprising Partnership That Determines Fate in Cystic Fibrosis
Discover how the cross-talk between ubiquitylation and SUMOylation pathways determines CFTR protein fate in cystic fibrosis and leads to innovative treatments.
Capturing Nature's Tiniest Dances: How X-Rays Reveal the Secret Lives of Proteins
Explore how high-flux X-ray scattering and rapid mixing microchannel devices reveal protein dynamics in real-time, with applications in disease research and molecular biology.
The Hidden Science of Muscle Loss: Why Inactivity Shrinks Your Muscles
Explore the molecular mechanisms behind skeletal muscle disuse atrophy, including signaling pathways, protein metabolism, and research advances.
Cellular Sabotage and the Scissors That Fix It: The Hunt for Deubiquitinases
Explore the fascinating world of deubiquitinases (DUBs) - the molecular scissors that regulate protein destruction in cells and their implications for treating cancer and neurodegenerative diseases.
The Immortalizer: How a Genetic Accident Creates Unstoppable Cancer Cells
Explore the fascinating science behind API2-MALT1 fusion protein and its role in creating apoptosis-resistant cancer cells in MALT lymphoma.
Disarming Cancer's Master Switch: How a Molecular Wrench Could Halt Tumors
Explore how mutant EGFR proteins interact with Hsp90 chaperones and how Geldanamycin triggers their degradation in cancer treatment.
The Missing Key: How UBE3A and Its Lost Substances Cause Angelman Syndrome
Understanding Angelman Syndrome through the substrate perspective - how missing UBE3A protein disrupts brain function and current therapeutic approaches.