Research Articles
The Unlikely Betrayal: How a DNA Repairman Helps Deactivate a Cancer-Fighting Hero
Discover how XPC protein collaborates with MDM2 to degrade p53 tumor suppressor, revealing new insights into cancer mechanisms and potential therapies.
The Cell's Double Agent: How a Stress Protein Switches Sides to Fight Cancer
Discover how the stress protein ATF3 acts as a molecular double agent, stabilizing p53 by competing with MDM2 to fight cancer development.
The Guardian's Betrayal: When the Body's Cancer Defense Turns Rogue
Explore how mutations in the MDM2 protein can subvert the body's natural cancer defenses and contribute to tumor development.
A Molecular Trojan Horse: New Hope in the Fight Against Leukemia
Discover how PROTAC molecular technology is revolutionizing leukemia treatment by degrading cancer-causing proteins with unprecedented efficacy.
Unlocking p53's Potential: The Gene Signature Predicting Cancer Drug Success
Discover how a 13-gene signature predicts response to MDM2 inhibitors in p53 wild-type cancers, enabling personalized therapy approaches.