Research Articles
Cool-1 and c-Cbl: The Cellular Sabotage Behind Glioblastoma and How Science Is Fighting Back
Discover how Cool-1 and c-Cbl proteins influence glioblastoma development and the promising therapeutic approaches targeting this cellular mechanism.
The Great Escape: How Cells Dispose of Misfolded Proteins
Explore the fascinating process of ER-associated degradation and the central role of Hrd1 in retrotranslocation of misfolded proteins.
How a Cellular "Bodyguard" Drives a Rare Leukemia
Discover how USP7 protein stabilizes NOTCH1 in T-cell acute lymphoblastic leukemia, creating new therapeutic opportunities for cancer treatment.
MLN4924: How a Cellular "Brake" Could Revolutionize Mantle Cell Lymphoma Treatment
A groundbreaking approach to cancer therapy targeting the neddylation pathway offers new hope for aggressive blood cancers like mantle cell lymphoma.
When the Brain's Recycling System Fails: How Proteasome Depletion Triggers Neurodegeneration
Discover how 26S proteasome dysfunction in mouse brain neurons leads to neurodegeneration and Lewy-like inclusions resembling human pale bodies.
Beyond the Needle: A New Liquid Biopsy for the Diabetic Kidney
Discover how urine proteome analysis is revolutionizing early detection of diabetic nephropathy through non-invasive liquid biopsy techniques.
Beyond Destruction: The Surprising Dual Life of the Hakai Protein
Discover the fascinating dual roles of Hakai protein - from cellular destruction to mRNA regulation and its implications for cancer research.
Cellular Housekeeping: How New Molecules Could Stop Muscle Waste
Discover how belactosin A and C proteasome inhibitors could revolutionize treatment for muscle wasting diseases through groundbreaking research on rat skeletal muscle.
How Influenza Hijacks Our Cellular Machinery: The Role of SUMOylation
Explore how influenza viruses manipulate the cellular SUMOylation process to enhance replication and evade immune defenses, with implications for antiviral therapies.
The Hidden Highway: How Wnt Signaling Drives Acute Myeloid Leukemia
Explore how the ancient Wnt signaling pathway becomes hijacked in acute myeloid leukemia, fueling cancer stem cells and driving treatment resistance.