Research Articles
How Legionella Bacteria Hijack Our Cellular Defense System: The Ubiquitin Story
Explore how Legionella pneumophila manipulates the ubiquitin system to survive and thrive in eukaryotic host cells through sophisticated molecular piracy.
The Double-Agent in Our Cells: How RBBP6 Plays Both Sides in the Fight Against Cancer
Discover how RBBP6 protein acts as both cancer suppressor and promoter, its role in breast and cervical cancer, and potential therapeutic applications.
The Cellular Janitor: How a Tiny Enzyme Could Hold the Key to a Rare Disease
Discover how deubiquitinase USP19 stabilizes phenylalanine hydroxylase and its implications for treating phenylketonuria (PKU).
UBR5: The Cellular Assassin Fighting Viral Invaders
Discover how UBR5 acts as an antiviral host factor against MERS-CoV by promoting ubiquitination and degradation of ORF4b protein.
Copper's Double Life: How a Dietary Metal Could Revolutionize Cancer Therapy
Discover how copper chelators interact with platinum drugs to fight resistant gastric cancer through innovative scientific approaches.
The Cellular Double Agent: How COP1 Tags a Tumor Suppressor for Destruction
Discover how COP1 functions as a ubiquitin ligase for PCDH9 ubiquitination and degradation, revealing critical mechanisms in cancer biology and neurological disorders.
Unleashing the Brakes: A New Weapon in the Fight Against Cancer
Discover how a new pan-Id protein antagonist shows remarkable promise in halting cancer growth by targeting previously 'undruggable' proteins.
RBX1: The Master Puppeteer Behind Triple-Negative Breast Cancer's Deadly Spread
Breakthrough research unveils how RBX1, a molecular machine, drives the aggressive metastasis of triple-negative breast cancer through ubiquitination pathways.
The Cell Cycle's Molecular Timekeeper: How RAP80 Degradation Prevents Cancer
Discover how RAP80 degradation regulated by Cdc20 and Cdh1 ubiquitin ligases prevents cancer through cell cycle control.
The Cellular Recycling Plant: How Your Cells Break Down Proteins to Stay Healthy
Discover the fascinating world of intracellular protein degradation, from the discovery of lysosomes to the revolutionary ubiquitin-proteasome system and its therapeutic applications.