Research Articles
The Case of the Molecular Zombie Enzymes: An Evolutionary Whodunit
Discover how OTU-family de-ubiquitylating enzymes lost their catalytic activity through evolution, becoming molecular zombies with new cellular functions.
The Cellular Cleanup Crew: How Protein Recycling Failures Drive Parkinson's Disease
Explore how failures in the ubiquitin-proteasome system contribute to Parkinson's disease pathology and potential therapeutic approaches.
P97: The Achilles' Heel of Cancer—How Targeting a Single Protein Could Revolutionize Cancer Treatment
Discover how targeting the p97 protein could revolutionize cancer treatment by eliminating cancer stem cells and overcoming treatment resistance.
The Protein Recyclers: How Thyroid Hormones Reshape Your Heart
Discover how thyroid hormones activate the ubiquitin-proteasome system to regulate cardiac hypertrophy and maintain heart health through protein quality control.
Molecular Glue Degraders: A Revolutionary Approach to Combat Treatment-Resistant Prostate Cancer
Discover how first-in-class molecular glue degraders target AR-V7 in treatment-resistant prostate cancer, offering new hope for patients.
Unlocking Diabetes: From Cellular Secrets to Life-Saving Solutions
Explore how diabetes research is translating cellular mechanisms into effective clinical treatments, from SGLT2 inhibitors to personalized medicine approaches.
Will Crystal Parkin Unlock the Future of Parkinson's Disease?
Explore how the discovery of Parkin's crystal structure is revolutionizing our understanding and treatment of Parkinson's disease.
Unlocking Leukemia's Secrets: How a Single Genetic Mutation Fuels a Rare Blood Cancer
Discover how SETBP1 mutations disrupt protein degradation in atypical chronic myeloid leukemia, driving cancer progression through impaired ubiquitination.
Taming the Overgrowth: How a Tiny Molecule Could Revolutionize Keloid Treatment
Discover how inhibiting miR-23b-3p could transform keloid treatment by restoring A20 function and normalizing fibroblast behavior.
Cracking the Cancer Code: How Scientists Are Untangling a Complex Tumor, One Cell at a Time
Discover how single-cell RNA sequencing is revealing the genetic diversity within chordoma tumors and paving the way for targeted cancer therapies.