Discover how the NEDD8 inhibitor pevonedistat blocks DNA repair and synergizes with TOP1 inhibitors to create more effective cancer treatments.
Explore how research conclusions bridge discovery and progress, with insights into scientific methodology and future research directions.
Explore the revolutionary PROTAC technology targeting alpha-synuclein for Parkinson's disease treatment through molecular degradation.
Explore the groundbreaking research on ZNRF1 and its role in neuronal protection therapy against neurodegenerative disorders.
Discover how preventing SUMOylation at lysine 75 could inhibit mutant SOD1 aggregation in ALS, offering new therapeutic approaches for this neurodegenerative disease.
Exploring the molecular mechanisms behind muscle stiffness in cerebral palsy through NCAM and ubiquitin research
Explore how resveratrol, a natural compound found in grapes and red wine, shows promise in fighting neurodegenerative diseases like Alzheimer's and Parkinson's through multiple protective mechanisms.
Discover how phospho-ubiquitin antibodies are revolutionizing Parkinson's research by revealing the cellular cleanup process of damaged mitochondria.
Explore how proteasomal subunits are revolutionizing cancer therapy through targeted inhibition and overcoming drug resistance in various cancers.
Discover how inhibiting the MSS1 protein suppresses neuroinflammation and offers new hope for treating Alzheimer's, Parkinson's, and Multiple Sclerosis.