Research Articles
The p53 Orchestra: How Ribosomal Protein S27a Conducts Cellular Defense Against Cancer
Exploring how ribosomal protein S27a regulates p53's tumor suppression activities and its dual role in cancer progression.
The Brain's Protein Recycling System: How Estrogen and Ubiquitin Shape Memory
Exploring how estrogen and the ubiquitin-proteasome system work together to regulate memory formation and why women face higher risks of memory-related disorders.
The Molecular Conductors: How CUL3 E3 Ligases Direct Plant Life
Exploring the critical role of CUL3 E3 ubiquitin ligases in plant development, hormone regulation, and stress responses.
The Tiny Ticks Costing Billions: How Vaccine Science is Fighting Back
Exploring how precision vaccines are combating the $30 billion global problem of cattle tick infestations through innovative science.
The Fra-1 Factor: How a Cancer Protein Hijacks Muscle Survival Pathways
Discover how Fra-1 protein orchestrates muscle wasting in cancer cachexia through mitochondrial dysfunction and apoptosis pathways.
The Ubiquitin Switch: How a Molecular Tag Team Forces Cancer Cells to Self-Destruct
Discover how the UBE4B-ITCH complex induces neuroblastoma cell death through K63/K48 branched polyubiquitination of Ku70 and c-FLIPL, enhancing HDACi-mediated apoptosis.
Viral Betrayal: How a Pathogen's Sabotage Sparked a Diagnostic Revolution
How scientists turned a viral enzyme's sabotage of immune protein ISG15 into a powerful diagnostic tool for detecting infections.
The SUMO Switch: How Blocking a Tiny Cellular Tag Could Revolutionize Cancer Therapy
Discover how inhibiting SUMOylation with TAK-981 reprograms immune defenses and transforms cancer treatment by awakening macrophage and NK cell functions.
Unlocking the Heart's Shield: How a Surgical Sedative Fights Cardiac Injury Through Cellular Recycling
Discover how dexmedetomidine (Dex) protects against myocardial ischemia-reperfusion injury by activating cellular autophagy through the PINK1/Parkin pathway.
Calycosin's Cancer Breakthrough: How a Plant Compound Fights Kidney Cancer
Discover how calycosin, a plant-derived flavonoid, inhibits renal cell carcinoma by targeting the MAZ/HAS2 signaling pathway.