Research Articles
The Invisible Shield: Unraveling the Mystery of Proteasome Inhibitor Resistance in Multiple Myeloma
Exploring the cellular mechanisms behind proteasome inhibitor resistance in multiple myeloma and emerging strategies to overcome this challenge in cancer treatment.
SENP1: The Molecular Master Switch in Cancer and a Promising New Therapeutic Target
Explore SENP1's role in cancer development, its molecular mechanisms, and promising therapeutic targeting strategies in this comprehensive scientific overview.
The Body's Hidden Clues: New Blood Tests Predict Recovery After Spinal Cord Injury
Emerging research into protein biomarkers in blood offers new ways to predict recovery after spinal cord injuries, with UCH-L1 showing particular promise.
Toppling the Tyrant: How Scientists Are Destabilizing the Master Oncoprotein in Ewing Sarcoma
Discover how researchers are targeting the EWS-FLI1 protein in Ewing Sarcoma through deubiquitinase inhibition, offering new hope for childhood cancer treatment.
How Cancer Hijacks Our Cellular Power Supply: The TRIM29 Story
Discover how TRIM29 reprograms glucose metabolism in colorectal cancer through pyruvate kinase manipulation and the Warburg effect.
The Cellular Guardians: How TRIM Proteins Fight Viruses and Brain Diseases
Explore the fascinating world of TRIM proteins and their dual therapeutic potential in combating viral infections and central nervous system diseases like Alzheimer's and Parkinson's.
The RFWD2 Puzzle: How a Cellular Ubiquitin Ligase Drives Cancer Growth and Drug Resistance
Exploring how RFWD2, an E3 ubiquitin ligase, drives multiple myeloma progression and proteasome inhibitor resistance through P27 degradation.
The Unlikely Pair: How a Sugar-Binding Protein Teams Up with DNA's Guardian to Fight Cancer
Discover the groundbreaking research revealing how galectin-3 interacts with BARD1 to influence DNA damage repair and cancer treatment resistance.
Cellular Cleanup Crew: How Parkin-Mediated Mitophagy Protects Kidneys from Fatty Acid Damage
Discover how Parkin-mediated mitophagy protects kidney cells from fatty acid damage through cellular quality control mechanisms and potential therapeutic applications.
The Ubiquitin Universe: How a Tiny Protein Molecule Shapes Life and Fights Disease
Explore the fascinating world of ubiquitin and ubiquitin-like signals - the sophisticated cellular communication system that regulates protein function and holds therapeutic promise.