Research Articles
The Copper Custodians: How Cellular Cleanup Crews Maintain Mineral Balance
Exploring how the ubiquitin proteasome system regulates copper homeostasis and its implications in disease
The DOT1L Destroyer: How a Molecular Pac-Man Could Revolutionize Leukemia Treatment
Discover how the first-in-class DOT1L PROTAC degrader MS2133 could revolutionize treatment for MLL-rearranged leukemia by completely eliminating the cancer-causing protein.
The Genetic Goldmine: Unlocking Bali Cattle's Potential Through Myostatin Secrets
Exploring how myostatin promoter polymorphisms could revolutionize Bali cattle breeding programs through enhanced muscling and fat deposition traits.
The Ubiquitin Assassins: How SCF E3 Ligases Became Cancer's Most Wanted Targets
Exploring how SCF E3 ubiquitin ligases function in cancer and the therapeutic strategies targeting these molecular complexes.
The Hypoxia Trap: How a Tiny Protein Fuels Osteosarcoma's Deadly Spread
Discover how hypoxia-induced WSB1 protein drives osteosarcoma metastasis and the potential therapeutic strategies targeting this pathway.
The VHL Hijack: How a Broken Cellular Cleanup Crew Fuels Kidney Cancer—and How Science Is Fighting Back
Exploring how VHL protein dysfunction drives kidney cancer and the innovative therapies targeting this pathway.
Hijacking the Cell's Recycling System: The Revolutionary Science of Targeted Protein Degradation
Explore the groundbreaking science of targeted protein degradation (TPD), a revolutionary strategy that hijacks the cell's natural disposal systems to eliminate disease-causing proteins.
The Silent Conductors: How TRAF3 and TRAF5 Orchestrate Our Immune Symphony
Exploring the crucial roles of TRAF3 and TRAF5 proteins in immune system regulation and their implications for disease treatment.
The Secret Weapon Inside Salt-Tolerant Plants: How Ubiquitin Warriors Battle Salinity
Discover how ubiquitin-like modifiers help plants survive salt stress through protein recycling, signaling, and autophagy mechanisms.
The Proteasome's Achilles' Heel: How Targeting RPN13 Could Revolutionize Ovarian Cancer Treatment
Exploring RPN13 as a novel therapeutic target for ovarian cancer treatment, focusing on its role in the proteasome system and potential to overcome chemotherapy resistance.