Research Articles
The β-Grasp Fold: From Ubiquitin's Structure to Versatile Functions and Therapeutic Targeting
This article provides a comprehensive resource for researchers and drug development professionals on the β-grasp fold, a structurally simple yet functionally versatile protein scaffold.
From APF-1 to Ubiquitin: The Discovery of the Molecular Kiss of Death and Its Impact on Biomedicine
This article chronicles the foundational discovery of ATP-dependent proteolysis factor 1 (APF-1), later identified as the universal protein ubiquitin, which revolutionized the understanding of intracellular protein degradation.
From Discovery to Therapy: The Historical Journey and Modern Impact of the Ubiquitin-Proteasome System
This article provides a comprehensive exploration of the Ubiquitin-Proteasome System (UPS), tracing its foundational discovery in the 1980s to its current status as a pivotal target in precision medicine.
Ubiquitin Code: Decoding the Molecular Nexus of DNA Repair and Immune Signaling in Disease and Therapy
This article synthesizes current research on ubiquitination, an essential post-translational modification that acts as a central regulatory node connecting DNA damage repair with immune response pathways.
Decoding Atypical Ubiquitin Chains: K6, K11, K27, K29, K33 Functions in Cellular Regulation and Disease
This article provides a comprehensive exploration of atypical ubiquitin chain linkages (K6, K11, K27, K29, K33), targeting researchers, scientists, and drug development professionals.
Decoding the Ubiquitin Code: From Molecular Complexity to Therapeutic Innovation
This article comprehensively explores the sophisticated architecture and functional diversity of the ubiquitin code, a critical post-translational regulatory system.
Ubiquitin-Like Proteins: From Ancient Origins to Modern Drug Discovery
This article provides a comprehensive synthesis of ubiquitin-like proteins (UBLs), exploring their conserved β-grasp fold structure, intricate enzymatic conjugation cascades, and profound evolutionary lineage tracing back to prokaryotic sulfur-transfer systems.
Beyond Degradation: The Expanding Universe of Non-Proteolytic Ubiquitin Signaling in Health and Disease
Once thought to function predominantly as a tag for proteasomal degradation, ubiquitin is now recognized as a versatile signaling molecule regulating key non-proteolytic processes.
How Neddylation Acts as the Master Conductor of Cellular Receptors
Explore how neddylation controls cellular receptor fate through molecular tagging, influencing brain development, cancer progression, and therapeutic applications.
Cutting Cancer's Master Switch: How Repurposing Old Drugs Offers New Hope Against USP22
Exploring how drug repurposing targets USP22, a key protein in cancer progression and treatment resistance, offering new anticancer therapeutic approaches.