Research Articles
Beyond the Blueprint: How a Tiny Molecular Wardrobe Transforms Proteins
Explore how chemical modifications transform peptides and small proteins, unlocking their functional potential through structural changes.
Cellular Housekeeping: How Protein Degradation Shapes Our Health and Fights Disease
Explore the fascinating world of intracellular protein degradation, from lysosomes and the ubiquitin-proteasome system to revolutionary therapies targeting human diseases.
Choking the Supply Lines: How a Cellular Factor Surprises Scientists by Starving Tumors
Discover how CTGF protein inhibits angiogenesis by degrading HIF-1α, offering new cancer therapy approaches.
The Silent Saboteur in Your Joints: How a Molecular Key Could Unlock Osteoarthritis Relief
Discover how a ubiquitin-competitive strategy targeting the USP7 protein could revolutionize osteoarthritis treatment by addressing the cellular imbalance at its core.
The Heart's Hidden Conversation: How a Low-Oxygen Signal Rewires Our Most Vital Muscle
Discover how hypoxia-inducible factor 1 regulates SERCA2 in the heart through miR-29c modulation, revealing new insights into heart function and potential therapies.
The Protein Puzzle: Unlocking Huntington's Disease with a Molecular Key
How a clever trick with a SUMO tag is helping scientists see the true culprit behind Huntington's disease by generating native, untagged huntingtin exon1 monomers and fibrils.
The BRCA1 Ubiquitin Ligase: The Cellular Guardian That Marks Proteins for Destiny
Explore how BRCA1 functions as a ubiquitin ligase enzyme, identifying its key substrates and understanding its crucial role in maintaining cellular health and preventing cancer.
The Cancer Engine: How a Vicious Metabolic Cycle Drives Tumor Aggressiveness
Discover how the GLS1-c-Myc positive feedback loop drives cancer progression and new therapeutic strategies to break this vicious cycle.
The SUMO System: How a Tiny Molecular Guardian Protects Our DNA During Cellular Stress
Discover how SUMO proteins and SUMO-interacting motifs protect our DNA during replication stress and maintain genomic stability.
Shattering Cancer's Shield: The Revolutionary Bispecific Antibodies That Degrade c-MET in NSCLC
Discover how c-MET degrading bispecific antibodies (EpiTACs) are revolutionizing treatment for NSCLC and other c-MET driven tumors through targeted protein degradation.